Wkrótce przeniosła się do Los Angeles, łącząc studia aktorskie w szkole teatralnej na Uniwersytecie Południowej Kalifornii z pracą na planie westernu Kraj dla twardzieli (Hard Country, 1981) u boku Jana-Michaela Vincenta i Kim Basinger oraz dramatu telewizyjnego ABC Papierowe lalki (Paper Dolls, 1982) z Joan Collins i Erikiem Stoltzem.
Jej ekscentryczna uroda i sprawność fizyczna zachwyciła publiczność i krytykę w roli agresywnej replikantki Pris w thrillerze sci-fi Ridleya Scotta Łowca androidów (Blade Runner, 1982).
From the mid-70s to the mid-80s, Daryl and John would score six #1 singles, including Rich Girl (also #1 R&B), Kiss on My List, Private Eyes, I Cant Go For That (No Can Do) (also #1 R&B), Maneater and Out of Touch from their six consecutive multi-platinum albums76s .
The era would also produce an additional 5 Top 10 singles, Sara Smile, One on One, You Make My Dreams, Say It Isnt So and Method of Modern Love. recognized Daryl Hall and John Oates as the NUMBER-ONE SELLING DUO in music history, a record they still hold today.
Daryl also wrote the H&O single "Everytime You Go Away," which singer Paul Young scored a number-one hit with a cover of the song in 1985. Daryl has recorded such solo works as have featured a mix of well-known performers like Train, Rob Thomas, Smokey Robinson, The Doors Robby Krieger and Ray Manzarek, Nick Lowe, K. Tunstall, Todd Rundgren, Gym Class Heroes Travis Mc Coy, Fall Out Boys Patrick Stump, Finger Elevens James Black and Rick Jackett, the Bacon Brothers and country star Jimmy Wayne, along with newcomers such as Philly soul singer Mutlu, Canadian techno-rockers Chromeo, pop-rock phenom Eric Hutchinson, Cash Money rocker Kevin Rudolf, Wind-up Records Chicago rockers Company of Thieves, Bay Area singer/songwriter Matt Nathanson, Charlottesville, VAs rising Parachute, Plain White Ts, Fitz and the Tantrums, Diane Birch and Sharon Jones and The Dap Kings.